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![]() "Because new approaches to treating pancreatic cancer are badly needed, we are pleased to work with DeMelle to give patients more therapeutic options." Malafa, a surgical oncologist in the Department of Gastrointestinal Oncology at Moffitt. "With this agreement, DeMelle can build on the research done at Moffitt, and bring novel treatments to patients that have the potential to be safer and more effective," said Dr. DM3001 also demonstrated superior activity compared to standard of care, Gemcitabine. ![]() ![]() In animal studies, DM3001 inhibited pancreatic and colon cancer growth and metastasis through suppression of cancer stem cells by the NF-κB, STAT3, WNT and RAS/KRAS/MAPK/AKT pathways. In this study, DM3001 penetrated the pancreatic stromal barrier to produce regulated cell death in tumor cells with a minimal effect on normal tissue. In a Phase 1b clinical study of 25 pre-surgical pancreatic cancer patients, DM3001 demonstrated promising activity with minimal adverse events. "DeMelle plans to continue building on the significant scientific advancements achieved by Mokenge Malafa, M.D., and his colleagues at Moffitt, with the potential to bring novel treatments that modulates the novel Exportin-2 target," said George Bobotas, Ph.D., CEO of DeMelle OncoPharma. Based on the underlying biology, lead-product candidate DM3001 (Farnesyl-Di-Methyl-Chromanol) is also expected to treat and prevent a broad range of other cancers, currently under exploration. Under the terms of the agreement, DeMelle will utilize Moffitt's technology as a platform for developing innovative treatments against cancers expressing the novel Exportin-2 target. TARPON SPRINGS, FL / ACCESSWIRE / Ma/ DeMelle OncoPharma LLC ("DeMelle" or the "Company"), a clinical-stage biotechnology company, announced today an exclusive global licensing agreement with Moffitt Cancer Center to develop DM3001, a first-in-class targeted pancreatic cancer treatment. Well jeeze.that's a tough one.Company developing DM3001 as first-in-class treatment against novel cancer target "How would you rate the "sex appeal" of this product?" One of the questions I'm asked in this section is: Haven't had … read more any need to seek support, but I have no doubt it is as good as the unit. VALUE! When you combine quality, great sound, and super price. You can position (angle) this pickup however you choose, it sounds best on my Fender directly horizontal - towards the rear of the soundhole.Īlthough, I can get some pretty groovy tonality when I angle it!Ĭompared to.OK, I won't name names.some other far more pricey units, shall we say, I belive you could drop-kick this unit from Philly to Frisco, and it would sound perfect. Like I said, my Fender was REBORN after installing this unit. but it would be nice to have it included. I just tacked it to the pickguard with a small adhesive stip. One thing.the cord can rub against the high E string. This is a very durable device, and it's design is beautiful. I've always miced it when performing or recording.never owned a pick up.till now!īrothers and sisters, this lovely little pick up has REBORN my Fender! Strings included in limited time offer are Dean Markley acoustic strings … read more Whether it's the Award Winning Curly Maple Promag Plus sound-hole pickup, the ebony finished Grand Humbucking, the Gold Humbucking with Dean's special "hot B-Fix" and Gold Plated Jack, the Artist Instant-Mount piezo pickup (with internal or external mountings), or the Sweet Spot Under-The-Saddle bridge Pickup, Dean Markley has a pickup that's perfect for you. Each Dean Markley pickup is engineered with the performer in mind, providing the truest reproduction and the finest in reliability. Plug into Dean Markley's ProMag Plus acoustic pickup and see just how good your acoustic guitar can sound.ĭean Markley acoustic pickups are the best-selling pickups on the market today. An award wining 15-feet low noise, double-shielded cable terminated with a solderless 1/4-inch nickel jack gives you freedom of movement with no worry of noise or hum. ![]() ProMag is voiced and balanced at the factory for perfect string balance - treble strings and bass strings will ring out with the same volume. ProMag has gained recognition as the finest sounding acoustic pickup made. ProMag is unsurpassed.īeing a single coil pickup, the ProMag Plus has bell-like harmonics that sing like no other acoustical pickup. ProMag's perfect balance and maple wood housing give it that smooth, high-end response that you want from an acoustic pickup. Dean Markley's ProMag Plus acoustical pickup has become an industry standard. ![]() All in all NeatMP3 Pro is the perfect companion for anybody that has a huge music collection and wants to organize it fast and simple, without having to deal with. NeatMP3 Pro saves all the processing information in a log file that can be accessed by the user from within the application. NeatMP3 supports all the commonly used audio file formats (MP3, OGG, FLAC, WAV, MPC, AIFF, ASF, MP4) and also benefits from additional features like saving the current setting as profiles for later use, logging, deleting the source photos after processing and even allows you to play the songs that you are organizing.Īll these features combined make NeatMP3 a very powerful music organizing tool that every music enthusiast should have. NeatMP3 also allows customizable manual tag editing. ![]() Want to manually edit your tags? No problem! NeatMP3 also allows manual id3 tag editing and offers support for Unicode characters. This MP3 audio converter also supports video to audio conversion. Besides, the converter provides optional options for target audio include audio bitrate and audio sample rate. It only takes three simple steps to finish your MP3 audio conversion. If the audio files that you are trying to organize have incomplete or invalid tags NeatMP3 will automatically take care of them by removing the invalid tags and filling the incomplete tags with information extracted from the names of the original files. NeatMP3 Update NeatMP3 Help NeatMP3 Help for Mac Help & Support If you have questions about NeatMP3 or want to report an issue, just send an e-mail to the following address: . Audio Converter is an easy-to-use app for Android users to convert audio files offline or online. Get a perfectly organized music collection in just three easy steps. Just select a set of audio files, choose the way in which your files will be organized and renamed from a wide set of commonly used predefined patterns, select the location where you want your files to be moved and you're ready to go. ![]() With NeatMP3 you can merge, organize, rename and edit the tags of your audio files in a single processing session. NeatMP3 is a free yet powerful music organizer software that will enable you to easily merge, organize, rename and edit the tags of all the audio files on your computer.ĭo you have thousands of poorly labeled music files scattered all around your hard drive that are just waiting to be organized and renamed? This is where NeatMP3 comes in with its intuitive interface and powerful organizing engine. ![]() ![]() According to the creators, such paints emphasize the atmosphere of unhindered communication and freedom of expression. It contrasts nicely with the white, adding a welcoming aura to the logo. The company representatives themselves call it Biurple, although, in reality, it is a shade of blue-violet # 7298DA. It looks like how Ive always seen it cause I never paid that close attention. The color palette is completely preserved. The letters are light, streamlined, showing the friendliness and openness of the application. They chose a softer typeface for the second option with rounded bold lowercase characters. The left side “D” has been cropped at an angle, showing an acute angle. Font and Colorsįor the first version of the logo, the developers created an original font based on Uni Sans Heavy and Compose Black. In addition, the designers got rid of the dialog box and transferred the blue-purple color to the robot, which was previously white. All letters (except for the first one) are converted to the lowercase format. Significant changes were made to the lettering: instead of the “robotic” font with a truncated “D,” a practical, rounded typeface appeared. The bottom stroke has been shortened a little, making the smile seem more restrained now. For example, the top spikes (antennae) have merged with the main body of the head to become trapezoidal protrusions similar to ears. ![]() This is done to attract new users and encourage them to communicate.Īfter a redesign for the 6th anniversary of the messenger and social network Discord, the shape of the Clyde robot has remained the same. The style is modern but friendly: the bottom semi-circular ledge resembles a smile, and many corners are smoothed. Get free Discord logo icons in iOS, Material, Windows and other design styles for web, mobile, and graphic design projects. Discord, a VoIP platform designed for creating communities, recently introduced a new logo and a refreshed new look to celebrate turning 6. The robot’s head is inside the dialogue cloud, which is very symbolic, given Discord’s focus. Download 27400 free Discord logo Icons in All design styles. The logo depicts the main mascot of the app, so the designers paid attention to detail. Rozpocznij proces projektowania logo, wpisujc nazw swojej firmy. The first release of the app dates back to 2015. It is suitable for different operating systems (iOS, Android, Windows, macOS, Linux) and supports many languages. This is the name of the free messenger, which belongs to the company of the same name. But the official version of Discord is completely different: the logo features a robot named Clyde – a benevolent character who helps users of the messenger. This explanation sounds plausible because the service was created for gamers. It consists of two parts: on the left, there is a blue dialog cloud with a graphic symbol, and on the right, there is a stylized inscription “DISCORD.” The hand-drawn element looks abstract and resembles a game console controller with short handles. The application has its icon, which is easy to recognize. |
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