![]() "Because new approaches to treating pancreatic cancer are badly needed, we are pleased to work with DeMelle to give patients more therapeutic options." Malafa, a surgical oncologist in the Department of Gastrointestinal Oncology at Moffitt. "With this agreement, DeMelle can build on the research done at Moffitt, and bring novel treatments to patients that have the potential to be safer and more effective," said Dr. DM3001 also demonstrated superior activity compared to standard of care, Gemcitabine. ![]() ![]() In animal studies, DM3001 inhibited pancreatic and colon cancer growth and metastasis through suppression of cancer stem cells by the NF-κB, STAT3, WNT and RAS/KRAS/MAPK/AKT pathways. In this study, DM3001 penetrated the pancreatic stromal barrier to produce regulated cell death in tumor cells with a minimal effect on normal tissue. In a Phase 1b clinical study of 25 pre-surgical pancreatic cancer patients, DM3001 demonstrated promising activity with minimal adverse events. "DeMelle plans to continue building on the significant scientific advancements achieved by Mokenge Malafa, M.D., and his colleagues at Moffitt, with the potential to bring novel treatments that modulates the novel Exportin-2 target," said George Bobotas, Ph.D., CEO of DeMelle OncoPharma. Based on the underlying biology, lead-product candidate DM3001 (Farnesyl-Di-Methyl-Chromanol) is also expected to treat and prevent a broad range of other cancers, currently under exploration. Under the terms of the agreement, DeMelle will utilize Moffitt's technology as a platform for developing innovative treatments against cancers expressing the novel Exportin-2 target. TARPON SPRINGS, FL / ACCESSWIRE / Ma/ DeMelle OncoPharma LLC ("DeMelle" or the "Company"), a clinical-stage biotechnology company, announced today an exclusive global licensing agreement with Moffitt Cancer Center to develop DM3001, a first-in-class targeted pancreatic cancer treatment. Well jeeze.that's a tough one.Company developing DM3001 as first-in-class treatment against novel cancer target "How would you rate the "sex appeal" of this product?" One of the questions I'm asked in this section is: Haven't had … read more any need to seek support, but I have no doubt it is as good as the unit. VALUE! When you combine quality, great sound, and super price. You can position (angle) this pickup however you choose, it sounds best on my Fender directly horizontal - towards the rear of the soundhole.Īlthough, I can get some pretty groovy tonality when I angle it!Ĭompared to.OK, I won't name names.some other far more pricey units, shall we say, I belive you could drop-kick this unit from Philly to Frisco, and it would sound perfect. Like I said, my Fender was REBORN after installing this unit. but it would be nice to have it included. I just tacked it to the pickguard with a small adhesive stip. One thing.the cord can rub against the high E string. This is a very durable device, and it's design is beautiful. I've always miced it when performing or recording.never owned a pick up.till now!īrothers and sisters, this lovely little pick up has REBORN my Fender! Strings included in limited time offer are Dean Markley acoustic strings … read more Whether it's the Award Winning Curly Maple Promag Plus sound-hole pickup, the ebony finished Grand Humbucking, the Gold Humbucking with Dean's special "hot B-Fix" and Gold Plated Jack, the Artist Instant-Mount piezo pickup (with internal or external mountings), or the Sweet Spot Under-The-Saddle bridge Pickup, Dean Markley has a pickup that's perfect for you. Each Dean Markley pickup is engineered with the performer in mind, providing the truest reproduction and the finest in reliability. Plug into Dean Markley's ProMag Plus acoustic pickup and see just how good your acoustic guitar can sound.ĭean Markley acoustic pickups are the best-selling pickups on the market today. An award wining 15-feet low noise, double-shielded cable terminated with a solderless 1/4-inch nickel jack gives you freedom of movement with no worry of noise or hum. ![]() ProMag is voiced and balanced at the factory for perfect string balance - treble strings and bass strings will ring out with the same volume. ProMag has gained recognition as the finest sounding acoustic pickup made. ProMag is unsurpassed.īeing a single coil pickup, the ProMag Plus has bell-like harmonics that sing like no other acoustical pickup. ProMag's perfect balance and maple wood housing give it that smooth, high-end response that you want from an acoustic pickup. Dean Markley's ProMag Plus acoustical pickup has become an industry standard.
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